The Samsung 9100 Pro 4TB is the objective winner, securing victories in six out of seven comparable specifications. Its most significant advantage is a sequential read speed that is 187% better than the competition. This performance lead makes it the superior choice for users prioritizing raw data throughput and high-capacity storage needs. While the Western Digital WD Blue SN5000 2TB falls behind in most technical categories, it maintains a distinct advantage with an MSRP that is 82% better.

Choose the Samsung 9100 Pro 4TB if your workflow demands maximum sequential read performance and you require the larger 4TB capacity for your system. Conversely, the Western Digital WD Blue SN5000 2TB is the appropriate selection for budget-conscious buyers who prioritize a lower MSRP over the performance and capacity advantages offered by the alternative. Select the drive that best aligns with your specific requirements for speed versus initial acquisition cost.