The Samsung 9100 Pro 4TB is the objective winner of this comparison, securing more individual specification victories than its competitor. While both drives share several identical technical attributes, the Samsung 9100 Pro 4TB holds a decisive lead in total storage space, offering a 100% capacity advantage over the Lexar NM1090 Pro 2TB. This significant increase in available room for data makes it the superior choice for users prioritizing maximum storage density for their systems.

Users who require extensive storage for large libraries or professional workloads should select the Samsung 9100 Pro 4TB to take advantage of its superior capacity. Conversely, the Lexar NM1090 Pro 2TB is the better option for budget-conscious buyers, as it provides a 46% advantage in MSRP. Choosing between these two components depends entirely on whether your primary requirement is the most affordable entry point or the largest possible volume of onboard storage.