The Samsung 9100 Pro 4TB is the objective winner of this comparison, securing victories in six out of seven measured specifications. Its most significant advantage over the Kingston NV2 500GB is its endurance, which is 1400% higher in terms of total bytes written. While the Kingston NV2 500GB holds a 94% advantage in MSRP, the Samsung 9100 Pro 4TB dominates the technical performance metrics across the board.

Users prioritizing long-term reliability and high-capacity storage should choose the Samsung 9100 Pro 4TB, as its superior endurance rating makes it better suited for heavy write workloads. Conversely, the Kingston NV2 500GB is the appropriate selection for budget-conscious buyers who need a basic storage solution and prioritize a lower MSRP over the extended lifespan and capacity offered by the alternative.