The Samsung 9100 Pro 4TB is the objective winner of this comparison, securing victory in four out of six measured specifications. Its most significant advantage is its sequential read performance, which is 2543% better than that of the Crucial MX500 2TB. While the Crucial MX500 2TB maintains a lead in MSRP, which is 79% better than the alternative, the Samsung 9100 Pro 4TB dominates the technical metrics across the board.

Users prioritizing raw speed and maximum storage capacity should choose the Samsung 9100 Pro 4TB for its superior sequential read capabilities. Conversely, the Crucial MX500 2TB is the appropriate selection for budget-conscious buyers who prioritize a lower MSRP over the performance advantages offered by the higher-capacity drive. Selecting between these two components depends entirely on whether your primary requirement is high-speed data access or minimizing your initial financial investment.