The MSI MAG B460 TOMAHAWK is the objective winner of this comparison, securing a higher number of superior specifications across the evaluated fields. Its most impactful advantage is the memory slot configuration, which offers a 100% improvement over the alternative. This hardware lead makes it the more robust choice for users prioritizing memory capacity and expansion potential within their system build, as it outperforms the MSI PRO B660M-A WIFI DDR4 in the majority of measured categories.

Users who require maximum memory capacity should select the MSI MAG B460 TOMAHAWK for its significant advantage in memory slots. Conversely, the MSI PRO B660M-A WIFI DDR4 is the better option for those who prioritize connectivity, as it provides a 100% improvement in USB Type-C support. Choosing between these two motherboards depends entirely on whether your specific workflow demands the expanded memory architecture of the former or the enhanced peripheral interface offered by the latter.