The Gigabyte B650M DS3H is the objective winner of this comparison, securing more total spec victories than its competitor. Its most significant advantage is the inclusion of additional M.2 slots, which provides a 100% improvement in storage expansion capability compared to the MSI PRO H610M-E DDR4. This hardware configuration makes the Gigabyte board the superior choice for users who prioritize internal storage capacity and future-proofing their system with multiple high-speed drives.

Users who require extensive storage options should select the Gigabyte B650M DS3H to leverage its superior M.2 slot count. Conversely, the MSI PRO H610M-E DDR4 is the appropriate choice for budget-conscious builders, as it offers a 36% advantage in MSRP. By choosing the MSI board, buyers can allocate their remaining funds elsewhere while still meeting the baseline requirements for a functional motherboard, provided they do not need the extra storage connectivity found on the Gigabyte model.