The ASUS ROG STRIX Z790-E GAMING WIFI is the objective winner of this comparison, securing victories in ten out of thirteen evaluated specifications. Its most significant advantage over the MSI PRO H610M-E DDR4 is the inclusion of M.2 slots, which provides a 400% improvement in storage expansion capacity. This substantial lead in connectivity and high-speed storage support establishes the ASUS board as the superior option for users requiring extensive hardware integration and modern storage configurations.

Users should choose the ASUS ROG STRIX Z790-E GAMING WIFI if they prioritize high-density storage and advanced system expansion. Conversely, the MSI PRO H610M-E DDR4 is the better selection for those who specifically require additional PCIe x1 slots, where it maintains a 100% advantage. Selecting between these two motherboards depends entirely on whether your build demands the superior M.2 storage capacity of the ASUS model or the specialized PCIe expansion offered by the MSI alternative.