The ASUS ROG MAXIMUS Z890 EXTREME is the objective winner of this comparison, securing victory across eight of the fourteen evaluated specifications. Its most impactful advantage is the USB Type-C connectivity, which offers a 300% improvement over the alternative. While the ASUS ROG STRIX Z490-E GAMING holds its own in four categories, the superior data transfer and peripheral support provided by the newer model establish it as the more capable hardware option for modern high-end builds.

Users prioritizing cutting-edge connectivity and the latest interface standards should select the ASUS ROG MAXIMUS Z890 EXTREME to leverage its significant USB Type-C advantage. Conversely, the ASUS ROG STRIX Z490-E GAMING remains the logical choice for those who specifically require a higher density of PCIe x1 slots, where it maintains a 100% advantage. Choosing between these two motherboards depends entirely on whether your workflow demands modern high-speed ports or specialized expansion card support.