The NVIDIA RTX 5080 is the objective winner of this comparison, securing victories in eleven out of thirteen measured categories. Its most significant advantage over the NVIDIA GTX 1660 Ti is its FP32 performance, which is 935% higher. While the older card maintains a lead in MSRP, the newer model dominates the technical specifications across the board, providing a massive leap in raw computational capability for demanding workloads.

Users prioritizing maximum performance should select the NVIDIA RTX 5080 to leverage its superior FP32 output. Conversely, the NVIDIA GTX 1660 Ti remains the appropriate choice for budget-conscious buyers, as it holds a 72% advantage in MSRP. Choosing between these two components depends entirely on whether your primary requirement is the highest possible technical performance or a lower initial cost.