The NVIDIA RTX 4080 is the objective winner of this comparison, securing victory in ten out of twelve measured specifications. Its most significant advantage over the NVIDIA GeForce GTX 1650 is its FP32 performance, which is 1536% higher. This massive disparity in raw computational power establishes the former as the superior hardware choice for demanding tasks, while the latter remains limited by its older architecture across the vast majority of the evaluated technical categories.

Users requiring maximum computational throughput should select the NVIDIA RTX 4080 to leverage its substantial lead in FP32 performance. Conversely, the NVIDIA GeForce GTX 1650 is the appropriate choice for budget-conscious buyers who prioritize its 88% advantage in MSRP. By choosing based on these specific strengths, consumers can align their purchase with either the high-performance capabilities of the newer card or the cost-efficiency offered by the entry-level model.