The NVIDIA RTX A6000 is the objective winner of this comparison, securing victory in eight out of twelve measured specifications. Its most significant advantage over the competition is its VRAM capacity, which is 500% better than that of the alternative. While the NVIDIA GTX 1080 manages to win in three categories, the substantial memory lead held by the RTX A6000 establishes it as the superior hardware option based on the provided technical data.

Users who prioritize maximum memory capacity for intensive workloads should select the NVIDIA RTX A6000 to leverage its massive VRAM advantage. Conversely, the NVIDIA GTX 1080 is the appropriate choice for budget-conscious buyers, as it holds an 87% advantage in MSRP. Choosing between these two components depends entirely on whether your primary requirement is the superior memory density of the RTX A6000 or the significant cost efficiency offered by the GTX 1080.