The NVIDIA RTX 5060 Ti 16 GB is the objective winner of this comparison, securing victory in eleven out of thirteen measured categories. Its most significant technical advantage over the NVIDIA GTX 1080 is its FP16 performance, which is 16829% higher. While the older card maintains a lead in memory bus width, the newer model dominates the vast majority of the hardware specifications provided, establishing itself as the superior component in this head-to-head evaluation.

Users should choose the NVIDIA RTX 5060 Ti 16 GB if they prioritize the massive gains in FP16 performance offered by the modern architecture. Conversely, the NVIDIA GTX 1080 remains the appropriate selection for specific use cases that rely heavily on a wider memory bus, where it holds a 100% advantage. Selecting between these two components depends entirely on whether your workload benefits more from the newer card's computational throughput or the older card's memory bus configuration.