The NVIDIA RTX 4080 SUPER is the objective winner, securing victory in ten out of thirteen comparable specifications. Its most significant advantage over the NVIDIA GTX 1080 is its FP16 performance, which is 37200% higher. While the older card maintains a lead in power efficiency, the massive disparity in computational throughput establishes the newer model as the superior hardware choice for modern processing demands.

Users prioritizing raw computational power and advanced performance capabilities should choose the NVIDIA RTX 4080 SUPER. Conversely, the NVIDIA GTX 1080 remains the appropriate selection for those who specifically require a lower TDP, as it is 44% more efficient in that regard. Selecting between these two components depends entirely on whether your primary requirement is the extreme increase in processing performance or the specific power consumption advantage offered by the older architecture.