The NVIDIA RTX 4060 Ti 16 GB is the objective winner of this comparison, securing victories in eleven out of thirteen measured specifications. Its most significant technical advantage over the NVIDIA GTX 1080 is its FP16 performance, which is 15657% higher. While the older card maintains a lead in memory bus width, the newer model dominates the vast majority of the evaluated hardware categories, establishing a clear lead in overall architectural capability.

Users should choose the NVIDIA RTX 4060 Ti 16 GB if they prioritize the massive gains in FP16 performance provided by the modern architecture. Conversely, the NVIDIA GTX 1080 remains the appropriate selection for specific use cases that rely on a wider memory bus. By weighing these two distinct hardware advantages against their specific computing needs, users can determine which component better aligns with their technical requirements.