The NVIDIA RTX 3090 Ti is the objective winner of this comparison, securing nine spec victories against the three held by the NVIDIA GTX 1080. The most significant technical advantage provided by the RTX 3090 Ti is its FP16 performance, which is 28471% better than that of the GTX 1080. This massive disparity in computational capability establishes the RTX 3090 Ti as the superior hardware option across the vast majority of the measured specifications.

Users prioritizing raw computational power and high-end performance should select the NVIDIA RTX 3090 Ti for its substantial lead in FP16 processing. Conversely, those who are strictly focused on initial cost efficiency should choose the NVIDIA GTX 1080, which maintains a 70% advantage in MSRP. The decision between these two components rests entirely on whether the buyer requires the extreme performance capabilities of the newer card or the significant cost savings offered by the older model.