The NVIDIA RTX 5080 is the objective winner of this comparison, securing victories in ten out of thirteen measured specifications. Its most significant technical advantage over the NVIDIA GTX 1080 Ti is its FP16 performance, which is 31167% higher. While the older card maintains a lead in memory bus width, the massive disparity in computational throughput makes the newer architecture the clear superior choice across the vast majority of evaluated hardware metrics.

Users prioritizing raw computational power and modern architectural efficiency should select the NVIDIA RTX 5080 for its overwhelming lead in FP16 performance. Conversely, the NVIDIA GTX 1080 Ti remains a viable option for specific use cases that rely heavily on a wider memory bus, where it holds a 38% advantage. Choose the former for general performance superiority or the latter if your specific workload demands the unique benefits of its memory interface configuration.