The NVIDIA RTX 5060 is the objective winner of this comparison, securing victory in ten out of thirteen measured specifications. Its most significant advantage over the NVIDIA GTX 1080 Ti is its FP16 performance, which is 10556% higher. While the older card maintains a lead in memory bus width, the newer model dominates the majority of technical categories, establishing itself as the superior option based on the provided hardware specifications.

Users prioritizing modern computational efficiency should choose the NVIDIA RTX 5060 for its massive lead in FP16 performance. Conversely, the NVIDIA GTX 1080 Ti remains the appropriate selection for specific tasks that rely heavily on a wider memory bus, where it maintains a 175% advantage. Select the former for general technical superiority or the latter if your specific workload requires the unique memory architecture benefits provided by the older hardware.