The NVIDIA RTX 4080 SUPER is the objective winner, securing victory in ten out of thirteen comparable specifications. Its most significant advantage over the NVIDIA GTX 1080 Ti is its FP16 performance, which is 28911% higher. While the older card maintains a lead in memory bus width by 38%, the massive disparity in computational throughput makes the newer model the superior choice across the vast majority of technical metrics provided.

Users prioritizing raw computational power and modern processing capabilities should select the NVIDIA RTX 4080 SUPER for its overwhelming lead in FP16 performance. Conversely, the NVIDIA GTX 1080 Ti remains a viable option for specific use cases that rely heavily on a wider memory bus. Choose the former for overall technical dominance or the latter if your specific workload benefits from the 38% advantage in memory bus width.