The NVIDIA RTX 4060 is the objective winner of this comparison, securing victories in nine out of thirteen measured specifications. Its most significant advantage is its FP16 performance, which is 8294% better than that of the NVIDIA GTX 1080 Ti. While the older card maintains a lead in memory bus width, the newer architecture provides a substantial leap in computational efficiency across the majority of the evaluated technical categories.

Users prioritizing modern computational throughput and architectural efficiency should select the NVIDIA RTX 4060 for its superior FP16 performance. Conversely, the NVIDIA GTX 1080 Ti remains a viable choice for specific workloads that rely heavily on a wider memory bus, where it maintains a 175% advantage over the newer model. Your decision should depend on whether your primary requirements favor raw memory bandwidth or the significantly higher processing capabilities of the current generation.