The NVIDIA RTX 5080 is the objective winner of this comparison, securing victory in nine out of fourteen measured specifications. Its most significant technical advantage is its shader unit count, which is 425% higher than that of the AMD RX 7600. While the latter holds its own in a few specific metrics, the former demonstrates a clear lead in raw hardware capacity across the majority of the evaluated categories.

Choose the NVIDIA RTX 5080 if your primary requirement is maximum shader performance for demanding graphical tasks. Conversely, the AMD RX 7600 is the superior choice for budget-conscious users, as it offers a 73% advantage in MSRP. Selecting between these two components depends entirely on whether you prioritize the substantial hardware superiority of the former or the significant cost efficiency provided by the latter.