The NVIDIA RTX 5080 is the objective winner of this comparison, securing victory in eleven out of fourteen measured specifications. Its most significant technical advantage is its FP32 performance, which is 431% better than that of the AMD RX 6600 XT. While the latter component holds its own in a few categories, the sheer scale of the performance lead held by the NVIDIA RTX 5080 makes it the superior choice for raw computational power.

Users prioritizing maximum performance should select the NVIDIA RTX 5080 to leverage its substantial lead in FP32 capabilities. Conversely, the AMD RX 6600 XT is the appropriate choice for budget-conscious buyers, as it offers a 62% better MSRP than the alternative. By choosing based on these specific advantages, you can align your purchase with either the highest possible processing output or the most favorable initial cost provided by these two hardware options.