The AMD RX 6750 XT is the objective winner of this comparison, securing more total spec victories than the AMD RX 6500 XT. While the latter holds a significant 64% advantage in MSRP, the former provides a much more robust hardware foundation. The most impactful technical superiority of the AMD RX 6750 XT is its VRAM capacity, which is 200% better than that of the AMD RX 6500 XT, offering a substantial increase in memory resources.

Users prioritizing budget constraints should select the AMD RX 6500 XT for its superior MSRP advantage. Conversely, those who require higher memory capacity for their workloads should choose the AMD RX 6750 XT. By leveraging the 200% VRAM advantage, the AMD RX 6750 XT is the clear choice for users whose primary requirement is expanded memory overhead, whereas the AMD RX 6500 XT remains the appropriate option for those focused strictly on the lower MSRP.