The NVIDIA RTX 5080 is the objective winner of this comparison, securing victory in eleven out of fourteen measured specifications. Its most significant advantage is its FP32 performance, which is 1481% better than that of the AMD RX 6400. While the latter component maintains a lead in power efficiency, the massive disparity in raw computational capability establishes the NVIDIA RTX 5080 as the superior hardware choice across the vast majority of technical metrics.

Users prioritizing raw computational power should select the NVIDIA RTX 5080 to leverage its substantial lead in FP32 performance. Conversely, the AMD RX 6400 is the appropriate choice for those who specifically require a low-power solution, as it offers an 85% advantage in TDP. Choosing between these two components depends entirely on whether your primary requirement is maximizing processing throughput or minimizing power consumption within your system configuration.