The NVIDIA RTX 4080 SUPER is the objective winner of this comparison, securing victories in eleven out of fourteen measured categories. Its most significant advantage over the AMD RX 6400 is its FP32 performance, which is 1367% better. While the AMD RX 6400 maintains a lead in three specific areas, the substantial gap in raw computational power establishes the NVIDIA RTX 4080 SUPER as the superior component based on the provided technical specifications.

Users prioritizing maximum computational throughput should choose the NVIDIA RTX 4080 SUPER for its massive lead in FP32 performance. Conversely, the AMD RX 6400 is the appropriate selection for buyers focused on the MSRP, where it holds an 84% advantage. Selecting between these two components depends entirely on whether your primary requirement is the highest possible performance capability or the most favorable initial purchase price as defined by these specific metrics.