The NVIDIA RTX 4060 Ti 16 GB is the objective winner of this comparison, securing victories in twelve out of fourteen measured categories. Its most significant advantage is its FP32 performance, which is 520% better than that of the AMD RX 6400. This massive lead in raw computational capability establishes the NVIDIA card as the superior option for users prioritizing high-end processing power and overall technical specifications.

Choose the NVIDIA RTX 4060 Ti 16 GB if your primary goal is maximizing performance for demanding tasks. Conversely, select the AMD RX 6400 if your build requires extreme power efficiency, as it holds a 68% advantage in TDP. While the NVIDIA card dominates in computational throughput, the AMD alternative remains the logical choice for systems where minimizing power draw is the most critical requirement.