The NVIDIA RTX 3080 is the objective winner of this comparison, securing a lead across the majority of the evaluated specifications. Its most significant advantage is found in its shader units, which provide a 1033% increase over the AMD RX 6400. While the latter component remains competitive in specific areas, the substantial disparity in core processing hardware establishes the former as the superior option for raw technical capability.

Users prioritizing maximum processing power should choose the NVIDIA RTX 3080 to leverage its massive shader unit advantage. Conversely, the AMD RX 6400 is the better selection for those who prioritize power efficiency, as it offers an 83% improvement in TDP. Selecting between these two components depends entirely on whether your primary requirement is the high-performance architecture of the former or the energy-conscious design of the latter.