The AMD RX 6400 is the objective winner of this comparison, securing victory across seven of the thirteen evaluated specifications. Its most significant technical advantage is its FP16 performance, which is 3861% better than that of the NVIDIA GTX 1080 Ti. While the latter component maintains a substantial lead in memory bus width, the superior FP16 capabilities of the AMD RX 6400 provide a decisive edge in the overall spec-based assessment.

Users prioritizing modern architectural efficiency and the specific advantages of higher FP16 performance should select the AMD RX 6400. Conversely, those who require the significantly larger memory bus offered by the NVIDIA GTX 1080 Ti should choose that component instead. Your final decision should depend on whether your specific workload relies more heavily on the advanced FP16 processing power of the AMD card or the expanded memory bus capacity provided by the NVIDIA alternative.