The AMD Radeon RX 6500 XT 8 GB is the objective winner of this comparison, securing victory in eight out of thirteen measured specifications. Its most significant advantage over the AMD RX 6400 is its VRAM capacity, which is 100% higher. While the AMD RX 6400 maintains a lead in power efficiency with a 50% better TDP, the superior memory configuration allows the AMD Radeon RX 6500 XT 8 GB to outperform its counterpart across the majority of technical categories.

Users prioritizing memory capacity for their graphical tasks should select the AMD Radeon RX 6500 XT 8 GB to take advantage of its doubled VRAM. Conversely, the AMD RX 6400 is the better choice for builds where power efficiency is the primary concern, as it offers a 50% improvement in TDP. Choose the former for higher memory headroom or the latter if minimizing power consumption is the most critical requirement for your specific system configuration.