The AMD RX 6750 XT is the objective winner of this comparison, securing victory in ten out of fourteen measured specifications. Its most significant advantage over the AMD RX 5500 XT is its VRAM capacity, which is 200% better. While the AMD RX 5500 XT holds a 69% advantage in MSRP, the superior hardware configuration of the AMD RX 6750 XT makes it the more capable component across the vast majority of technical categories.

Users prioritizing maximum hardware specifications and increased memory capacity should select the AMD RX 6750 XT for their build. Conversely, the AMD RX 5500 XT is the appropriate choice for those who identify the MSRP as their primary concern. By choosing based on these specific advantages, buyers can align their purchase with either the high-capacity performance of the former or the cost-focused positioning of the latter.