The NVIDIA RTX 5060 Ti 16 GB is the objective winner of this comparison, securing victories in nine out of thirteen measured specifications. Its most significant advantage over the AMD RX 480 is its FP32 performance, which is 307% higher. While the AMD RX 480 maintains a notable lead in memory bus width, offering a 100% improvement in that specific category, the overall technical superiority of the NVIDIA RTX 5060 Ti 16 GB makes it the more capable hardware option.

Users prioritizing raw computational power and modern processing capabilities should select the NVIDIA RTX 5060 Ti 16 GB for its substantial lead in FP32 performance. Conversely, the AMD RX 480 remains a relevant choice for specific use cases that rely heavily on a wider memory bus architecture. Choosing between these two components depends entirely on whether your workload demands the massive increase in floating-point throughput or the specific memory bus configuration provided by the older hardware.