The NVIDIA RTX 4080 SUPER is the objective winner of this comparison, securing victory in nine out of thirteen measured specifications. Its most significant advantage is its FP32 performance, which is 796% better than that of the AMD RX 480. This massive lead in raw computational capability establishes the NVIDIA card as the superior component across the vast majority of technical metrics evaluated in this head-to-head analysis.

Users prioritizing raw computational power and modern technical specifications should choose the NVIDIA RTX 4080 SUPER for their build. Conversely, the AMD RX 480 remains a viable option for those focused strictly on the initial MSRP, where it maintains an 80% advantage over the competitor. Selecting between these two components depends entirely on whether your primary requirement is the highest possible performance ceiling or the most favorable starting cost.