The Noctua NH-U12S Redux wins in 2 out of 3 comparable specs. Its biggest advantage is MSRP (62% better).
EK-AIO 280 D-RGB wins in 1 spec (TDP Rating: 76% better).
Recommendation
Choose NH-U12S Redux if you want the best overall performance — especially msrp.
Choose EK-AIO 280 D-RGB if tdp rating matters more to you.