The Lian Li Lancool 216 is the objective winner of this comparison, securing more victories across the evaluated specifications. Its most impactful advantage over the Fractal Design Meshify 2 Compact is its superior capacity for 3.5" storage drives, which represents a 50% increase in support. While both cases offer distinct configurations, the Lian Li Lancool 216 provides a more robust foundation for users prioritizing high-capacity mechanical storage within their build.

Users who require extensive space for 3.5" hard drives should select the Lian Li Lancool 216 to take advantage of its higher drive capacity. Conversely, the Fractal Design Meshify 2 Compact is the better choice for those who prioritize 2.5" drive support, as it offers a 100% advantage in that specific category. Choosing between these two cases depends entirely on whether your storage configuration relies more heavily on smaller solid-state drives or larger mechanical units.